Even though a lot of progress has been made in spotting the genetic causes of some cancers, it has become evident that changes in the primary DNA sequence alone cannot elucidate the steps that are essential to turn a normal cell into a cancer cell. Two research papers demonstrate that miR-22 impels the onset and spread of breast cancer in mouse models as well as the factors that identify the onset of blood cancer. The research findings were carried out by a research team at Beth Israel Deaconess Medical Center. Their findings suggested that inhibiting the mir-22 offers therapeutic option for treating hematological tumors. The research show an amazing fact that, this one little microRNA can activate cancer in two different organs, perhaps in many more, and can also promote metastasis in the case of breast cancer.
The research becomes exciting for several reasons such as microRNAs can reconfigure, could trigger epigenetic re-writing, repress certain genes by silencing a family of enzymes termed TET proteins, the tumor suppressors.
Science Daily, July 3, 2013